Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4868295 | 0.81 | ADRA1D (0.57) | ADRA1DCYP2D6SLC6A4HTR2AHTR7 | |
| SCHEMBL14306777 | 0.80 | ADRA1D (0.80) | ADRA1DCYP2D6SLC6A4 | |
| SCHEMBL4872035 | 0.80 | ADRA1D (0.56) | ADRA1DCYP2D6SLC6A4HTR2AHTR7 | |
| SCHEMBL11007868 | 0.79 | ADRA1D (0.61) | ALDH1A1MEN1KMT2AADRA1DCYP2D6 | |
| SCHEMBL7649189 | 0.77 | KDM4E (0.67) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4865515 | 0.77 | ADRA1D (0.64) | ADRA1DSLC6A4 | |
| SCHEMBL11047479 | 0.75 | ADRA1D (0.61) | ADRA1DCYP2D6SLC6A4HTR2AHTR7 | |
| SCHEMBL9671736 | 0.74 | HTR7 (0.67) | ADRA1DCYP2D6SLC6A4HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL7259157 | 0.74 | ADRA1D (0.90) | ADRA1DCYP2D6SLC6A4 | |
| SCHEMBL9032327 | 0.73 | ADRA1D (0.69) | ADRA1DCYP2D6SLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4522945-A | SEROTONINE ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-11 | — | — | US | disclosed |
| US-4335127-A | POTENT SEROTONIN ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-06-15 | — | — | US | disclosed |
| EP-0013612-A2 | (Piperidinylalkyl)quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-07-23 | — | — | EP | disclosed |