Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | UBE2N | P61088 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4981971 | 0.81 | HTR2A (0.67) | CYP2D6HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL5471202 | 0.81 | HTR2A (0.69) | CYP2D6HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL6802419 | 0.79 | HTR7 (0.57) | CYP2D6KDM4ECYP3A4CYP2C19HTR7 | |
| SCHEMBL9070717 | 0.78 | ADRA1D (0.65) | POLBCYP2D6CYP2C19LMNASMN1; SMN2 | |
| SCHEMBL6954538 | 0.77 | DRD2 (0.72) | CYP2D6HTR2AKDM4ECYP1A2CYP3A4 | |
| Lenperone SCHEMBL121686 | 0.77 | MEN1 (0.74) | CYP2D6HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL11440661 | 0.77 | SMN1; SMN2 (0.51) | POLBCYP2D6CYP2C19MEN1UBE2N | |
| Hydrochloric Acid SCHEMBL11620288 | 0.76 | DRD2 (0.71) | CYP2D6HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL6794897 | 0.76 | HTR7 (0.53) | CYP2D6KDM4ECYP3A4CYP2C19KMT2A | |
| Lenperone SCHEMBL11453463 | 0.76 | MEN1 (0.72) | CYP2D6HTR2AKDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4522945-A | SEROTONINE ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-11 | — | — | US | disclosed |
| EP-0013612-B1 | (PIPERIDINYLALKYL)QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-11-09 | — | — | EP | disclosed |
| US-4335127-A | POTENT SEROTONIN ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-06-15 | — | — | US | disclosed |
| EP-0013612-A2 | (Piperidinylalkyl)quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-07-23 | — | — | EP | disclosed |