Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4232196 | 0.84 | CYP2C9 (0.55) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| SCHEMBL10602457 | 0.84 | ADAMTS5 (0.40) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| SCHEMBL10601085 | 0.82 | HCAR2 (0.42) | MAPTADAM17ADAMTS5 | |
| SCHEMBL10597770 | 0.80 | MMP2 (0.42) | ALDH1A1MAPTAKR1B1MMP9MMP2 | |
| SCHEMBL10599566 | 0.78 | ADAMTS5 (0.36) | MAPTAKR1B1MMP2GAAADAM17 | |
| Trifluoroacetic Acid SCHEMBL1101339 | 0.77 | CYP2C9 (0.41) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| SCHEMBL20134939 | 0.76 | AKR1B1 (0.40) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| SCHEMBL20134941 | 0.76 | AKR1B1 (0.40) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| SCHEMBL11795914 | 0.74 | ALDH1A1 (0.44) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| SCHEMBL11790334 | 0.73 | CYP2C9 (0.46) | CYP2C9CACNA1FALDH1A1MAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4556670-A | Spiro-3-hetero-azolones for treatment of diabetic complications | PFIZER INC. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0115133-A1 | Spiro-3-hetero-azolones for treatment of diabetic complications | PFIZER INC. (US) | 1984-08-08 | — | — | EP | disclosed |