Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2046496 | 0.94 | NOS1 (0.34) | NOS1NOS2 | |
| SCHEMBL9676464 | 0.78 | CES2 (0.33) | THRB | |
| SCHEMBL11294271 | 0.73 | ALDH1A1 (0.36) | ALDH1A1EPHX1SCN2ATSHRTHRB | |
| SCHEMBL11605181 | 0.73 | ALDH1A1 (0.36) | ALDH1A1EPHX1SCN2ATSHRTHRB | |
| SCHEMBL11297716 | 0.73 | ALDH1A1 (0.36) | ALDH1A1EPHX1SCN2ATSHRTHRB | |
| SCHEMBL11426867 | 0.73 | ALDH1A1 (0.36) | ALDH1A1EPHX1SCN2ATSHRTHRB | |
| SCHEMBL11426866 | 0.73 | ALDH1A1 (0.36) | ALDH1A1EPHX1SCN2ATSHRTHRB | |
| SCHEMBL11605183 | 0.73 | ALDH1A1 (0.36) | ALDH1A1EPHX1SCN2ATSHRTHRB | |
| SCHEMBL11297718 | 0.73 | ALDH1A1 (0.36) | ALDH1A1EPHX1SCN2ATSHRTHRB | |
| SCHEMBL11776686 | 0.73 | ALDH1A1 (0.36) | ALDH1A1EPHX1SCN2ATSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105793239-B | Ultraviolet absorption compound, its composition and application thereof | 珊瑚防晒私人有限公司 | 2019-11-05 | — | — | CN | disclosed |
| CN-107266416-A | It is used as the aryl dihydropyridone and piperidones of MGAT2 inhibitor | 百时美施贵宝公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-107266416-A | It is used as the aryl dihydropyridone and piperidones of MGAT2 inhibitor | 百时美施贵宝公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-104080768-B | Aryldihydropyridinones and piperidones as MGAT2 inhibitors | 百时美施贵宝公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-102264700-B | Can be used as the dihydropyridine keto-amide of the medicine for the treatment of autoimmunization and inflammatory diseases | HOFFMAN-LA ROCHE LTD. (CH) | 2015-08-19 | — | — | CN | disclosed |
| CN-104080768-A | Aryldihydropyridinones and piperidones as MGAT2 inhibitors | BRISTOL MYERS SQUIBB CO | 2014-10-01 | — | — | CN | disclosed |
| EP-2393781-B1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-03-12 | — | — | EP | disclosed |
| WO-2013062887-A1 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS GPR131 AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |
| US-8153808-B2 | Dihydropyridone amides as P2X7 modulators | ROCHE PALO ALTO LLC (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153809-B2 | Dihydropyridone ureas as P2X7 modulators | ROCHE PALO ALTO LLC (US) | 2012-04-10 | — | — | US | disclosed |
| CN-1070907-A | Preparation 4-replaces-1, the novel method of 4-dihydropyridine | MERCK & CO INC (US) | 1993-04-14 | — | — | CN | disclosed |
| WO-1993006082-A1 | PROCESS FOR THE PREPARATION OF 4-SUBSTITUTED-1,4-DIHYDROPYRIDINES | MERCK & CO., INC. (US) | 1993-04-01 | — | — | WO | disclosed |
| EP-0534520-A2 | Process for the preparation of 4-substituted-1,4-dihydropyridines | MERCK & CO. INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5134167-A | 1-AZABUTADIENES AND FUNGICIDES CONTAINING THESE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 1992-07-28 | — | — | US | disclosed |
| US-4599341-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1986-07-08 | — | — | US | disclosed |
| US-4591587-A | CARDIOTONIC AGENTS | MERCK & CO., INC. (US) | 1986-05-27 | — | — | US | disclosed |
| US-4590276-A | Process for the preparation of cyclopropyl pyridine compounds useful as calcium channel blockers | MERCK & CO., INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4587253-A | Bridged pyridine compounds useful as calcium channel blockers and analgesics | MERCK & CO., INC. (US) | 1986-05-06 | — | — | US | disclosed |
| US-4548941-A | 1,5-Methano-1H-4-benzazonine dicarboxylates, process for preparing and use as calcium blockers | MERCK & CO., INC. (US) | 1985-10-22 | — | — | US | disclosed |
| US-4532237-A | Treating cardiovascular disorders | MERCK & CO., INC. (US) | 1985-07-30 | — | — | US | disclosed |