SCHEMBL11013003

SCHEMBL11013003

Nc1ccc2c(c1)sc1nc(-c3ccccc3)cn12

nearest known ligand 0.67

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.67
RAB9A P51151 3/20 0.67
TP53 P04637 3/20 0.67
SMN1; SMN2 Q16637 2/20 0.67
ATM Q13315 2/20 0.67
LMNA P02545 2/20 0.67
TSHR P16473 1/20 0.67
TDP1 Q9NUW8 1/20 0.67
NPC1 O15118 3/20 0.52
THRB P10828 3/20 0.52
ALDH1A1 P00352 2/20 0.52
RXFP1 Q9HBX9 1/20 0.52
APP P05067 1/20 0.49
KDM4E B2RXH2 1/20 0.48
POLB P06746 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11013010 0.89 MAPT (0.56) MAPTRAB9ATP53SMN1; SMN2ATM
SCHEMBL29925444 0.87 MAPT (0.55) MAPTRAB9ATP53SMN1; SMN2ATM
SCHEMBL3864616 0.86 LMNA (0.58) MAPTRAB9ATP53SMN1; SMN2ATM
Hydrochloric Acid SCHEMBL29924956 0.86 MAPT (0.54) MAPTRAB9ATP53SMN1; SMN2ATM
SCHEMBL24106082 0.83 LMNA (0.70) MAPTRAB9ATP53SMN1; SMN2ATM
SCHEMBL11011244 0.83 TP53 (0.67) MAPTRAB9ATP53SMN1; SMN2ATM
SCHEMBL20893101 0.83 TP53 (0.67) MAPTRAB9ATP53SMN1; SMN2ATM
SCHEMBL11010264 0.83 MAPT (0.53) MAPTRAB9ATP53SMN1; SMN2ATM
SCHEMBL74089 0.83 MAPT (0.52) MAPTRAB9ATP53SMN1; SMN2ATM
SCHEMBL84416 0.82 RAB9A (0.64) MAPTRAB9ATP53SMN1; SMN2ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220370431-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2022-11-24 US disclosed
US-4497817-A ANTIALLERGENS-IMMUNOSUPPRESSIVE AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1985-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220370431-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 MAPT 3215/4885RAB9A 2519/4885TP53 96/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.