Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11471176 | 0.87 | TDP1 (0.58) | L3MBTL1PTGS1PTGS2TDP1LMNA | |
| SCHEMBL11458749 | 0.85 | TDP1 (0.56) | L3MBTL1PTGS1PTGS2TDP1LMNA | |
| SCHEMBL27738099 | 0.84 | ALOX15 (0.49) | ALOX15GFERADAM17PKMHPGD | |
| SCHEMBL10707144 | 0.83 | KMT2A (0.47) | ALOX15GFERADAM17PKML3MBTL1 | |
| SCHEMBL10881708 | 0.82 | PTGS2 (0.52) | ALOX15GFERADAM17ATMALDH1A1 | |
| SCHEMBL4007061 | 0.82 | MEN1 (0.54) | HPGDL3MBTL1KMT2AMEN1PTGS1 | |
| SCHEMBL28449377 | 0.82 | HPGD (0.50) | HPGDL3MBTL1KMT2AMT-CO2ALDH1A1 | |
| SCHEMBL30827495 | 0.81 | ALOX15 (0.47) | ALOX15GFERADAM17PKML3MBTL1 | |
| SCHEMBL18358283 | 0.81 | ALOX15 (0.47) | ALOX15GFERADAM17PKML3MBTL1 | |
| SCHEMBL30660823 | 0.81 | KMT2A (0.45) | ALOX15GFERADAM17PKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190031599-A1 | INDANE DERIVATIVES AS MGLUR7 MODULATORS | TAKEDA CAMBRIDGE LIMITED (GB) | 2019-01-31 | — | — | US | disclosed |
| US-20190031599-A1 | INDANE DERIVATIVES AS MGLUR7 MODULATORS | TAKEDA CAMBRIDGE LIMITED (GB) | 2019-01-31 | — | — | US | disclosed |
| EP-3408256-A1 | INDANE DERIVATIVES AS MGLUR7 MODULATORS | Takeda Pharmaceutical Company Limited (JP) | 2018-12-05 | — | — | EP | disclosed |
| CN-108602760-A | Indane derivatives as MG L UR7 modulators | 武田药品工业株式会社 | 2018-09-28 | — | — | CN | disclosed |
| WO-2017131221-A1 | INDANE DERIVATIVES AS MGLUR7 MODULATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-08-03 | — | — | WO | disclosed |
| WO-2017131221-A1 | INDANE DERIVATIVES AS MGLUR7 MODULATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-08-03 | — | — | WO | disclosed |
| EP-0151702-A2 | Alpha-hydroxyketone acetals | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1985-08-21 | — | — | EP | disclosed |
| EP-0048136-A2 | Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1982-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190031599-A1 | INDANE DERIVATIVES AS MGLUR7 MODULATORS | GRM7, GRIN2B, GRM1 | ALOX15 4096/4885GFER 2726/4885ADAM17 4404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.