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SCHEMBL1101437

SCHEMBL1101437

Cc1c(N(CCCC(F)(F)F)S(=O)(=O)c2ccc(C(C)(C)O)cc2)sc2ccccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 5/20 0.49
▸ NR1I2 O75469 6/20 0.47
▸ RORC P51449 4/20 0.41
▸ NR1H2 P55055 6/20 0.39
▸ ESR2 Q92731 3/20 0.38
▸ ESR1 P03372 1/20 0.38
▸ KEAP1 Q14145 2/20 0.37
▸ NFE2L2 Q16236 2/20 0.37
▸ HSD11B1 P28845 1/20 0.37
▸ RORA P35398 2/20 0.35
▸ NR1H3 Q13133 2/20 0.35
▸ RORB Q92753 2/20 0.35
▸ NR1H4 Q96RI1 2/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ RXRA P19793 1/20 0.35
▸ SREBF1 P36956 1/20 0.35
▸ PSEN1 P49768 1/20 0.35
▸ PSEN2 P49810 1/20 0.35
▸ NR1I3 Q14994 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1099774 0.89 TRPM8 (0.52) TRPM8NR1I2RORCNR1H2ESR2
SCHEMBL1099379 0.86 TRPM8 (0.65) TRPM8
SCHEMBL1099626 0.86 TRPM8 (0.55) TRPM8NR1I2RORCESR2ESR1
SCHEMBL1098856 0.86 TRPM8 (0.51) TRPM8NR1I2RORCNR1H2ESR2
SCHEMBL1099706 0.84 TRPM8 (0.57) TRPM8RORCALDH1A1PSEN1PSEN2
SCHEMBL1099477 0.83 TRPM8 (0.64) TRPM8
SCHEMBL1100541 0.83 TRPM8 (0.47) TRPM8NR1I2RORCNR1H2ESR2
SCHEMBL1100499 0.82 TRPM8 (0.53) TRPM8NR1I2RORCNR1H2ESR2
SCHEMBL1107227 0.82 TRPM8 (0.46) TRPM8NR1I2RORCNR1H2ESR2
SCHEMBL1098736 0.81 TRPM8 (0.50) TRPM8ESR2ESR1KEAP1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9434711-B2 Sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, N.V. (BE) 2016-09-06 — — US disclosed
US-20140315899-A1 SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-10-23 — — US disclosed
US-8809327-B2 Sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2014-08-19 — — US disclosed
EP-2183239-B1 SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2012-08-22 — — EP disclosed
US-20120190674-A1 SULFONAMIDES AS TRPM8 MODULATORS BRANUM SHAWN T (US) 2012-07-26 — — US disclosed
US-8153682-B2 Sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2012-04-10 — — US disclosed
US-20090264474-A1 SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, N.V. (BE) 2009-10-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190674-A1 SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPM5, TRPM2 TRPM8 1/4885NR1I2 465/4885RORC 3514/4885
US-20140315899-A1 SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPM5, TRPM2 TRPM8 1/4885NR1I2 465/4885RORC 3514/4885
US-20090264474-A1 SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPM5, TRPM2 TRPM8 1/4885NR1I2 465/4885RORC 3514/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.