Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.58 |
| ▸ | PDE5A | O76074 | 3/20 | 0.58 |
| ▸ | PDE1A | P54750 | 3/20 | 0.58 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.58 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA4 | P22748 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11014379 | 1.00 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11024278 | 0.83 | LMNA (0.52) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11024269 | 0.83 | LMNA (0.52) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL10442451 | 0.79 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11014088 | 0.77 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL6685492 | 0.77 | CA2 (0.52) | CA2CA4CA9CA1ADORA2A | |
| SCHEMBL6685489 | 0.77 | CA2 (0.52) | CA2CA4CA9CA1ADORA2A | |
| SCHEMBL11017499 | 0.75 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9194840 | 0.74 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9373694 | 0.74 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157637-A2 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-10-09 | — | — | EP | disclosed |