Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA4 | P22748 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11024269 | 1.00 | LMNA (0.52) | LMNASMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL11014376 | 0.83 | PDE4A (0.58) | CA2CA4CA9ALDH1A1CA1 | |
| SCHEMBL11014379 | 0.83 | PDE4A (0.58) | CA2CA4CA9ALDH1A1CA1 | |
| Dimethylamine SCHEMBL11024282 | 0.81 | LMNA (0.51) | LMNASMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL11151054 | 0.81 | SMN1; SMN2 (0.67) | LMNASMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL11462599 | 0.78 | SMN1; SMN2 (0.84) | LMNASMN1; SMN2HTTNPSR1MEN1 | |
| Arprinocid SCHEMBL8375355 | 0.77 | ADORA2A (0.60) | LMNASMN1; SMN2HTTNPSR1MEN1 | |
| Arprinocid SCHEMBL31379008 | 0.77 | ADORA2A (0.60) | LMNASMN1; SMN2HTTNPSR1MEN1 | |
| Arprinocid SCHEMBL31025603 | 0.77 | ADORA2A (0.60) | LMNASMN1; SMN2HTTNPSR1MEN1 | |
| Arprinocid SCHEMBL126655 | 0.77 | ADORA2A (0.60) | LMNASMN1; SMN2HTTNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0076127-B1 | 6-AMIDINO-9-SUBSTITUTED BENZYL PURINES, THEIR PRODUCTION AND ANTICOCCIDIAL USE, AND COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1985-06-05 | — | — | EP | claimed |
| US-4407802-A | 6-Amidino-9-substituted benzyl purines | MERCK & CO., INC. (US) | 1983-10-04 | — | — | US | claimed |
| EP-0076127-A2 | 6-Amidino-9-substituted benzyl purines, their production and anticoccidial use, and compositions containing them | MERCK & CO. INC. (US) | 1983-04-06 | — | — | EP | claimed |
| EP-0076128-B1 | NOVEL PROCESS FOR THE PREPARATION OF N6-ALKYL-ARPRINOCID | MERCK & CO. INC. (US) | 1985-07-24 | — | — | EP | disclosed |
| EP-0076127-B1 | 6-AMIDINO-9-SUBSTITUTED BENZYL PURINES, THEIR PRODUCTION AND ANTICOCCIDIAL USE, AND COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1985-06-05 | — | — | EP | disclosed |
| US-4407802-A | 6-Amidino-9-substituted benzyl purines | MERCK & CO., INC. (US) | 1983-10-04 | — | — | US | disclosed |
| EP-0076127-A2 | 6-Amidino-9-substituted benzyl purines, their production and anticoccidial use, and compositions containing them | MERCK & CO. INC. (US) | 1983-04-06 | — | — | EP | disclosed |
| EP-0076128-A2 | Novel process for the preparation of N6-alkyl-arprinocid | MERCK & CO. INC. (US) | 1983-04-06 | — | — | EP | disclosed |
| US-4361699-A | Novel process for the preparation of N6 -alkyl-arprinocid | MERCK & CO., INC. (US) | 1982-11-30 | — | — | US | disclosed |