Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPG | P10696 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770670 | 0.93 | ALPG (0.55) | ALPGKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL11249330 | 0.83 | ALPG (0.55) | ALPGKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL29660149 | 0.82 | SMN1; SMN2 (0.48) | ALPGKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL18548584 | 0.82 | SMN1; SMN2 (0.48) | ALPGKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL10696645 | 0.81 | ALPG (0.53) | ALPGKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL11014908 | 0.80 | DHODH (0.40) | ALPGMAPTDHODHMEN1KMT2A | |
| SCHEMBL11015093 | 0.80 | PTAFR (0.42) | TBXAS1PTAFR | |
| SCHEMBL10848968 | 0.78 | TXNRD1 (0.47) | ALPGKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL11015097 | 0.78 | MEN1 (0.39) | ALPGKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL11018500 | 0.78 | ALPG (0.37) | ALPGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0006114-B1 | 7-METHOXY-5-OXO-5H-THIAZOLO(2,3-B)QUINAZOLIN-2-CARBOXYLIC ACID AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-04-07 | — | — | EP | claimed |
| US-4168380-A | ANTIALLERGEN | HOFFMANN-LA ROCHE INC. (US) | 1979-09-18 | — | — | US | claimed |
| EP-0142057-A2 | Thiazoloquinazoline derivatives, their preparation and pharmaceutical compositions containing same | F. HOFFMANN-LA ROCHE AG (CH) | 1985-05-22 | — | — | EP | disclosed |
| US-4282360-A | ANTIALLERGENS | HOFFMANN-LA ROCHE INC. (US) | 1981-08-04 | — | — | US | disclosed |
| EP-0006114-A1 | 7-Methoxy-5-oxo-5H-thiazolo(2,3-b)quinazolin-2-carboxylic acid and its pharmaceutically acceptable salts, process for their preparation and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-01-09 | — | — | EP | disclosed |
| US-4168380-A | ANTIALLERGEN | HOFFMANN-LA ROCHE INC. (US) | 1979-09-18 | — | — | US | disclosed |
| US-4168380-A | ANTIALLERGEN | HOFFMANN-LA ROCHE INC. (US) | 1979-09-18 | — | — | US | disclosed |
| US-4168380-A | ANTIALLERGEN | HOFFMANN-LA ROCHE INC. (US) | 1979-09-18 | — | — | US | disclosed |