Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017574 | 0.86 | NPSR1 (0.45) | HPGDKDM4ELMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL11020824 | 0.86 | CHEK2 (0.48) | LMNASMN1; SMN2NPSR1 | |
| SCHEMBL11017577 | 0.79 | CHEK2 (0.53) | LMNASMN1; SMN2NPSR1MAPTHDAC6 | |
| SCHEMBL11018423 | 0.79 | AMY1A (0.47) | LMNAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL11020833 | 0.78 | CHEK2 (0.58) | LMNASMN1; SMN2NPSR1 | |
| SCHEMBL5651447 | 0.76 | FLT3 (0.62) | LMNAMAPTFLT3HDAC3HDAC1 | |
| SCHEMBL11020057 | 0.75 | CHEK2 (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4CYP1A2 | |
| SCHEMBL5651251 | 0.75 | PRMT5 (0.50) | HPGDKDM4ELMNAALDH1A1GAA | |
| SCHEMBL9635925 | 0.75 | PDE5A (0.47) | HPGDKDM4ELMNAALDH1A1GAA | |
| SCHEMBL10733296 | 0.74 | PDE2A (0.46) | HPGDKDM4ELMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |