Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 17/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020833 | 0.92 | CHEK2 (0.58) | CHEK2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL11017574 | 0.91 | NPSR1 (0.45) | CHEK2PARP1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL11016715 | 0.86 | HPGD (0.43) | LMNASMN1; SMN2NPSR1 | |
| SCHEMBL11020236 | 0.85 | CHEK2 (0.48) | CHEK2PARP1PDE2A | |
| SCHEMBL11017577 | 0.83 | CHEK2 (0.53) | CHEK2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL11018423 | 0.83 | AMY1A (0.47) | LMNASMN1; SMN2NPSR1PDE2A | |
| SCHEMBL10748970 | 0.81 | CHEK2 (0.51) | CHEK2 | |
| SCHEMBL9635925 | 0.79 | PDE5A (0.47) | PARP1LMNASMN1; SMN2NPSR1PDE2A | |
| SCHEMBL10733296 | 0.79 | PDE2A (0.46) | PARP1LMNASMN1; SMN2NPSR1PDE2A | |
| SCHEMBL11022048 | 0.78 | CHEK2 (0.55) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |