Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 9/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | PDE4A | P27815 | 4/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017574 | 0.92 | NPSR1 (0.45) | CHEK2LMNASMN1; SMN2NPSR1TP53 | |
| SCHEMBL11020833 | 0.91 | CHEK2 (0.58) | CHEK2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL11019250 | 0.84 | CHEK2 (0.53) | CHEK2TP53MAPTTDP1POLB | |
| SCHEMBL11020824 | 0.83 | CHEK2 (0.48) | CHEK2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL11550692 | 0.81 | LMNA (0.43) | CHEK2LMNASMN1; SMN2NPSR1TP53 | |
| SCHEMBL20982494 | 0.81 | CHEK2 (0.62) | CHEK2SMN1; SMN2TP53MAPTTDP1 | |
| SCHEMBL10733296 | 0.79 | PDE2A (0.46) | LMNASMN1; SMN2NPSR1MAPT | |
| SCHEMBL11016715 | 0.79 | HPGD (0.43) | LMNASMN1; SMN2NPSR1MAPTHDAC6 | |
| SCHEMBL12470518 | 0.78 | POLB (0.54) | CHEK2LMNANPSR1TP53MAPT | |
| SCHEMBL9635925 | 0.78 | PDE5A (0.47) | LMNASMN1; SMN2NPSR1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |