Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.50 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 3/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | ADH5 | P11766 | 2/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020022 | 1.00 | PDE3B (0.50) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL11018454 | 0.81 | PDE3B (0.34) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11018450 | 0.81 | PDE3B (0.34) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10645524 | 0.79 | PDE3B (0.61) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL11017821 | 0.78 | PDE3B (0.46) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL11017825 | 0.78 | PDE3B (0.46) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL10647436 | 0.70 | PDE3B (0.44) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL10365361 | 0.69 | CYP11B1 (0.42) | ADH5 | |
| SCHEMBL10364015 | 0.69 | PDE3B (0.41) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL10648271 | 0.69 | PDE3A (0.59) | PDE3BPDE3APDE2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |