Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 7/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.59 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10647436 | 0.79 | PDE3B (0.44) | PDE3APDE3BPDE2ACYP1A2LMNA | |
| SCHEMBL10645524 | 0.78 | PDE3B (0.61) | PDE3APDE3BPDE2AKMT2AMEN1 | |
| SCHEMBL11017825 | 0.77 | PDE3B (0.46) | PDE3APDE3BPDE2ACYP1A2KMT2A | |
| SCHEMBL11017821 | 0.77 | PDE3B (0.46) | PDE3APDE3BPDE2ACYP1A2KMT2A | |
| SCHEMBL10650257 | 0.77 | PDE3B (0.62) | PDE3APDE3BPDE2ACYP1A2LMNA | |
| SCHEMBL10648447 | 0.75 | CYP1A2 (0.41) | PDE3APDE3BCYP1A2KMT2AMEN1 | |
| SCHEMBL10651151 | 0.75 | PDE3B (0.37) | PDE3APDE3BCYP1A2KMT2AMEN1 | |
| SCHEMBL10645457 | 0.75 | CYP11B1 (0.56) | PDE3APDE3BCYP1A2POLBTBXAS1 | |
| SCHEMBL10363591 | 0.75 | PDE3B (0.39) | PDE3APDE3BPDE2ACYP1A2KMT2A | |
| SCHEMBL7280366 | 0.74 | PDE3B (1.00) | PDE3APDE3BPDE2ACYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |