Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018257 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL11016212 | 0.77 | PDE3B (0.50) | KDM4ERAB9ASMN1; SMN2LMNANPC1 | |
| SCHEMBL11016210 | 0.77 | PDE3B (0.50) | KDM4ERAB9ASMN1; SMN2LMNANPC1 | |
| SCHEMBL11020105 | 0.73 | PDE3B (0.42) | CRBNPDE3BPDE3A | |
| SCHEMBL11020107 | 0.73 | PDE3B (0.42) | CRBNPDE3BPDE3A | |
| SCHEMBL10365507 | 0.72 | IDO1 (0.44) | LMNAMEN1KMT2AIDO1CYP11B1 | |
| SCHEMBL11020084 | 0.71 | RAB9A (0.45) | RAB9ASMN1; SMN2LMNANPC1IDO1 | |
| SCHEMBL11020085 | 0.71 | RAB9A (0.45) | RAB9ASMN1; SMN2LMNANPC1IDO1 | |
| SCHEMBL11048184 | 0.70 | PDE3B (0.34) | CYP11B1CYP11B2CRBNPDE3BPDE3A | |
| SCHEMBL11048182 | 0.70 | PDE3B (0.34) | CYP11B1CYP11B2CRBNPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |