Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 2/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11048182 | 1.00 | PDE3B (0.34) | PDE3BPDE3ACYP11B1CYP11B2PDE4A | |
| SCHEMBL11020084 | 0.73 | RAB9A (0.45) | PDE3BPDE3ACYP11B1CYP11B2PDE4A | |
| SCHEMBL11020085 | 0.73 | RAB9A (0.45) | PDE3BPDE3ACYP11B1CYP11B2PDE4A | |
| SCHEMBL11018257 | 0.70 | KDM4E (0.45) | PDE3BPDE3ACYP11B1CYP11B2CRBN | |
| SCHEMBL11018253 | 0.70 | KDM4E (0.45) | PDE3BPDE3ACYP11B1CYP11B2CRBN | |
| SCHEMBL11062828 | 0.69 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11062826 | 0.69 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10365507 | 0.68 | IDO1 (0.44) | CYP11B1CYP11B2 | |
| SCHEMBL11018273 | 0.65 | PDE3B (0.67) | PDE3BPDE3ACYP11B1CYP11B2PDE4A | |
| SCHEMBL11018276 | 0.65 | PDE3B (0.67) | PDE3BPDE3ACYP11B1CYP11B2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |