Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 15/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634871 | 0.83 | PDE5A (0.47) | AMY1AKDM4EALDH1A1TP53PDE10A | |
| SCHEMBL10742496 | 0.83 | PDE5A (0.43) | AMY1AKDM4EALDH1A1TP53PDE10A | |
| SCHEMBL11019179 | 0.80 | AMY1A (0.47) | AMY1APDE5A | |
| SCHEMBL10762222 | 0.78 | AMY1A (0.41) | AMY1AKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL11017329 | 0.76 | AR (0.50) | AMY1AKDM4EALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL11009297 | 0.76 | PDE5A (0.35) | AMY1AKDM4EALDH1A1TP53PDE10A | |
| SCHEMBL10748409 | 0.76 | AMY1A (0.56) | AMY1A | |
| SCHEMBL10737588 | 0.74 | PDE2A (0.42) | KDM4EALDH1A1TP53PDE10APDE5A | |
| SCHEMBL10760601 | 0.74 | MAPK10 (0.42) | AMY1ANPC1RAB9APDE5A | |
| SCHEMBL9635715 | 0.73 | PDE5A (0.47) | AMY1AKDM4EALDH1A1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |