Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 3/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017329 | 0.92 | AR (0.50) | AMY1AMAPK10ARF7PDE5A | |
| SCHEMBL11018943 | 0.92 | AMY1A (0.47) | AMY1AF7CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10760601 | 0.88 | MAPK10 (0.42) | AMY1AMAPK10PDE5APDE3BPDE3A | |
| SCHEMBL11017363 | 0.83 | AR (0.50) | AMY1AARF7CYP1A2CYP2C9 | |
| SCHEMBL10765326 | 0.81 | MAPK10 (0.42) | AMY1AMAPK10F7PDE5APKN1 | |
| SCHEMBL10748660 | 0.81 | CDK4 (0.46) | AMY1AMAPK10F7PDE5APDE3B | |
| SCHEMBL11021670 | 0.81 | PDE5A (0.38) | MAPK10PDE5ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11017897 | 0.80 | PDE4A (0.44) | AMY1ANPC1MAPT | |
| SCHEMBL10763275 | 0.80 | MAPK10 (0.42) | MAPK10PDE5APDE3BPDE3ACYP1A2 | |
| SCHEMBL11016458 | 0.79 | CHEK2 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209707-A2 | 2-Aryl imidazoles, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-01-28 | — | — | EP | disclosed |
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |