Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019023 | 0.92 | CHEK2 (0.48) | HPSEPOLBMEN1KMT2AHTT | |
| SCHEMBL11017271 | 0.89 | NPC1 (0.47) | HPSESMN1; SMN2CHEK2PLK1NPC1 | |
| SCHEMBL11018145 | 0.82 | NPC1 (0.45) | HPSEPOLBSMN1; SMN2CHEK2NPC1 | |
| SCHEMBL11017274 | 0.81 | CHEK2 (0.56) | HPSECHEK2NPC1RAB9AHSP90AA1 | |
| SCHEMBL11020863 | 0.79 | SMN1; SMN2 (0.44) | HPSEPOLBMEN1KMT2AHTT | |
| SCHEMBL10760161 | 0.79 | RHEB (0.47) | HPSEHTTSMN1; SMN2MAPTCHEK2 | |
| SCHEMBL11019173 | 0.78 | POLB (0.47) | HPSEPOLBMEN1KMT2AHTT | |
| SCHEMBL11021670 | 0.78 | PDE5A (0.38) | MEN1KMT2AMAPTRECQLCHEK2 | |
| SCHEMBL10759746 | 0.77 | NPC1 (0.44) | HPSEMEN1KMT2ACHEK2NPC1 | |
| SCHEMBL11020731 | 0.77 | NPC1 (0.44) | POLBMAPTTDP1CHEK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |