Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | RHEB | Q15382 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021674 | 0.92 | METAP2 (0.46) | PDE5ARHEBMETAP2METAP1PKN1 | |
| SCHEMBL10760601 | 0.88 | MAPK10 (0.42) | PDE5ARHEBPKN1PKN2MAPK10 | |
| SCHEMBL14514686 | 0.81 | RHEB (0.57) | PDE5ARHEBS1PR1METAP2METAP1 | |
| SCHEMBL10765326 | 0.81 | MAPK10 (0.42) | PDE5ARHEBPKN1PKN2MAPK10 | |
| SCHEMBL11018065 | 0.81 | PDE5A (0.37) | PDE5ARHEBS1PR1METAP2METAP1 | |
| SCHEMBL11022213 | 0.81 | ATR (0.44) | PDE5ATRPV4GUSBMAPT | |
| SCHEMBL10762222 | 0.81 | AMY1A (0.41) | PDE5ARHEBPKN1PKN2KDM4E | |
| Hydrochloric Acid SCHEMBL5647675 | 0.81 | RHEB (0.56) | PDE5ARHEBS1PR1METAP2METAP1 | |
| SCHEMBL11021081 | 0.81 | CA12 (0.43) | PDE5AS1PR1TRPV4GUSBMAPT | |
| SCHEMBL11018823 | 0.81 | TOP1 (0.40) | PDE5ARHEBS1PR1METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |