Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019019 | 0.92 | HPSE (0.42) | CHEK2POLBNPC1TP53MAPT | |
| SCHEMBL11017274 | 0.89 | CHEK2 (0.56) | CHEK2NPC1RAB9AF2F10 | |
| SCHEMBL11018149 | 0.82 | HDAC6 (0.52) | CHEK2POLBNPC1RAB9AF2 | |
| SCHEMBL11017271 | 0.81 | NPC1 (0.47) | CHEK2NPC1TP53RAB9AHPSE | |
| SCHEMBL11020867 | 0.79 | TP53 (0.51) | CHEK2POLBNPC1TP53MAPT | |
| SCHEMBL11019907 | 0.79 | CHEK2 (0.53) | CHEK2NPC1MAPTRAB9AL3MBTL1 | |
| SCHEMBL11019181 | 0.78 | TP53 (0.55) | CHEK2POLBNPC1TP53MAPT | |
| SCHEMBL11021674 | 0.78 | METAP2 (0.46) | CHEK2NPC1TP53MAPTRAB9A | |
| SCHEMBL11020734 | 0.77 | CHEK2 (0.54) | CHEK2POLBNPC1TP53MAPT | |
| SCHEMBL11017088 | 0.77 | CHEK2 (0.47) | CHEK2POLBNPC1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |