SCHEMBL11019201

SCHEMBL11019201

Cc1ccc2[nH]c(C(C(O)=S)C(O)=S)nc2c1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CBFB Q13951 1/20 0.41
EGLN1 Q9GZT9 1/20 0.41
ADAMTS5 Q9UNA0 1/20 0.36
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
MAPK1 P28482 1/20 0.33
PARP1 P09874 1/20 0.32
HCRTR1 O43613 1/20 0.31
HCRTR2 O43614 1/20 0.31
RPS6KA3 P51812 1/20 0.31
CHEK1 O14757 1/20 0.31
OPRM1 P35372 1/20 0.31
PDE2A O00408 1/20 0.31
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
P2RY12 Q9H244 1/20 0.31
USP2 O75604 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6757190 0.78 CBFB (0.46) CBFBEGLN1ADAMTS5NPC1RAB9A
SCHEMBL6753933 0.73 CBFB (0.42) CBFBEGLN1ADAMTS5NPC1RAB9A
SCHEMBL353026 0.70 CBFB (0.51) CBFBEGLN1ADAMTS5NPC1RAB9A
SCHEMBL6756285 0.68 CBFB (0.38) CBFBEGLN1ADAMTS5NPC1RAB9A
SCHEMBL1192237 0.67 NPC1 (0.50) CBFBEGLN1ADAMTS5NPC1RAB9A
SCHEMBL4386791 0.67 CBFB (0.49) CBFBEGLN1ADAMTS5NPC1RAB9A
SCHEMBL9144161 0.67 CBFB (0.49) CBFBEGLN1ADAMTS5NPC1RAB9A
SCHEMBL2541920 0.67 CBFB (0.49) CBFBEGLN1ADAMTS5KDM4EMAPT
SCHEMBL23227712 0.67 CBFB (0.45) CBFBEGLN1ADAMTS5NPC1RAB9A
SCHEMBL9304576 0.67 IDO1 (0.62) NPC1RAB9ASMN1; SMN2KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0161219-A2 Heterocyclic mercaptocarboxylic-acid esters and anhydrides as corrosion inhibiting agents CIBA-GEIGY AG (CH) 1985-11-13 EP disclosed