Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020513 | 1.00 | PDE3B (0.49) | PDE3BPDE3APTGS1PTGS2LMNA | |
| SCHEMBL11019471 | 0.79 | PDE3B (0.63) | PDE3BPDE3APTGS1PTGS2LMNA | |
| SCHEMBL11019458 | 0.79 | PDE3B (0.63) | PDE3BPDE3APTGS1PTGS2LMNA | |
| SCHEMBL10726946 | 0.78 | PDE3B (0.61) | PDE3BPDE3ALMNASMN1; SMN2GAA | |
| SCHEMBL11017552 | 0.78 | PDE3B (0.65) | PDE3BPDE3APTGS1PTGS2LMNA | |
| SCHEMBL11017553 | 0.78 | PDE3B (0.65) | PDE3BPDE3APTGS1PTGS2LMNA | |
| SCHEMBL10725018 | 0.72 | ALDH1A1 (0.53) | PDE3BPDE3AGAAPOLBMAPT | |
| SCHEMBL11018454 | 0.70 | PDE3B (0.34) | PDE3BPDE3AGAAMGAMSI | |
| SCHEMBL11018450 | 0.70 | PDE3B (0.34) | PDE3BPDE3AGAAMGAMSI | |
| SCHEMBL10647873 | 0.68 | PBRM1 (0.48) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |