Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019939 | 0.89 | HTR1B (0.46) | HTR1BRAB9ATP53MAPK1KDM4E | |
| SCHEMBL10677366 | 0.87 | HTR1B (0.44) | HTR1BRAB9ATP53MAPK1KDM4E | |
| SCHEMBL11018432 | 0.87 | TSHR (0.42) | HTR1BRAB9ATP53MAPK1KDM4E | |
| SCHEMBL11021541 | 0.87 | RAB9A (0.47) | HTR1BRAB9ATP53MAPK1KDM4E | |
| SCHEMBL10678598 | 0.84 | HTR1B (0.45) | HTR1BRAB9ATP53MAPK1KDM4E | |
| SCHEMBL11019776 | 0.83 | HTR1B (0.46) | HTR1BMAPK1KDM4ETSHRHPGD | |
| SCHEMBL11019533 | 0.83 | KDM4E (0.58) | HTR1BKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12230884 | 0.82 | ALDH1A1 (0.57) | HTR1BRAB9AMAPK1KDM4ETSHR | |
| SCHEMBL2804367 | 0.82 | ALDH1A1 (0.57) | HTR1BRAB9AMAPK1KDM4ETSHR | |
| SCHEMBL15923371 | 0.82 | ALDH1A1 (0.57) | HTR1BRAB9AMAPK1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157652-A1 | 2-, 3- And 4-biphenyloxyaminoalkanes and related compounds, their preparation and uses, and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1985-10-09 | — | — | EP | disclosed |