Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.56 |
| ▸ | GSK3A | P49840 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.56 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 14/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 10/20 | 0.42 |
| ▸ | TOP1 | P11387 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020049 | 0.84 | PIM1 (0.41) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL11021076 | 0.80 | PIM1 (0.32) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL9693946 | 0.74 | PIM1 (0.77) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL9694104 | 0.74 | PIM1 (0.77) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL9615970 | 0.74 | PIM1 (0.77) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL9675077 | 0.72 | PIM1 (0.72) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL10679579 | 0.72 | ALDH1A1 (0.66) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL10911645 | 0.72 | KCNH2 (0.47) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL9229314 | 0.71 | PIM1 (0.62) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL9228624 | 0.71 | PIM1 (0.62) | PIM1GSK3AGSK3BPIM3CSNK1G1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153163-A2 | 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |