Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.32 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CAT | P04040 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020992 | 0.80 | PIM1 (0.56) | PIM1GSK3AGSK3BPIM3PRKD3 | |
| SCHEMBL10911793 | 0.74 | KCNH2 (0.41) | KCNH2ALDH1A1 | |
| SCHEMBL9877122 | 0.74 | KCNH2 (0.36) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10950502 | 0.74 | EIF4A3 (0.39) | KCNH2 | |
| SCHEMBL11020858 | 0.73 | KCNH2 (0.32) | KCNH2KDM4EALDH1A1 | |
| SCHEMBL6004835 | 0.72 | POLB (0.34) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL6904311 | 0.70 | KMT2A (0.39) | KDM4EALDH1A1HPGD | |
| SCHEMBL16098745 | 0.67 | TOP2A (0.50) | KCNH2 | |
| SCHEMBL6341275 | 0.67 | HCAR2 (0.35) | PIM1GSK3AGSK3BPIM3PRKD3 | |
| SCHEMBL3802263 | 0.66 | PRKAB2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153163-A2 | 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |