Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.50 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.50 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004835 | 0.76 | POLB (0.34) | HCAR2 | |
| SCHEMBL6341275 | 0.74 | HCAR2 (0.35) | TOP2ATOP2BHCAR2 | |
| SCHEMBL6904417 | 0.70 | IDO1 (0.38) | KCNH2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL11021076 | 0.67 | PIM1 (0.32) | KCNH2 | |
| SCHEMBL6904311 | 0.67 | KMT2A (0.39) | — | |
| SCHEMBL7557799 | 0.67 | ALDH1A1 (0.51) | TOP2ATOP2B | |
| SCHEMBL16121059 | 0.67 | TOP2A (1.00) | TOP2ATOP2B | |
| SCHEMBL8061645 | 0.66 | DPP4 (0.39) | — | |
| SCHEMBL4237180 | 0.65 | PADI4 (0.36) | HCAR2 | |
| SCHEMBL10738605 | 0.65 | TOP2A (0.52) | TOP2ATOP2BCDC7MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014152895-A1 | MULTI-TIERED HIGH THROUGH-PUT SCREEN FOR COMPOUNDS EFFECTIVE AGAINST BACTERIAL BIOFILM AND COMPOUNDS EFFECTIVE FOR INHIBITING AND ERADICATING BACTERIAL BIOFILM | UNIVERSITY OF CINCINNATI (US) | 2014-09-25 | — | — | WO | disclosed |