Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11029744 | 0.90 | CYP2D6 (0.49) | CYP1A2CYP2D6KMT2AMEN1ALDH1A1 | |
| SCHEMBL11593239 | 0.87 | SIGMAR1 (0.50) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL11026149 | 0.85 | SIGMAR1 (0.50) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL11023837 | 0.83 | SIGMAR1 (0.51) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL25475206 | 0.82 | KMT2A (0.46) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL31618323 | 0.82 | CYP1A2 (0.56) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL12120100 | 0.82 | ALDH1A1 (0.49) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL23871039 | 0.82 | KMT2A (0.46) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| Bromide SCHEMBL17509812 | 0.81 | ALDH1A1 (0.57) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL25475236 | 0.81 | CYP1A2 (0.46) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040793-B1 | NOVEL QUINAZOLINE-DIONE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | Ishikawa, Masayuki (JP) | 1985-08-28 | — | — | EP | disclosed |
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |