Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11023837 | 0.98 | SIGMAR1 (0.51) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL11023682 | 0.89 | CYP2D6 (0.51) | CYP1A2CYP2D6KMT2AMEN1KDM4E | |
| SCHEMBL11026771 | 0.87 | MEN1 (0.51) | CYP1A2CYP2D6KMT2AMEN1MAPK1 | |
| SCHEMBL11023279 | 0.87 | CYP2D6 (0.49) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL11021089 | 0.85 | SIGMAR1 (0.48) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL11027681 | 0.83 | ALDH1A1 (0.47) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL9246829 | 0.82 | ALDH1A1 (0.51) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL9253983 | 0.82 | ALDH1A1 (0.51) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL11593239 | 0.82 | SIGMAR1 (0.50) | SIGMAR1CYP1A2CYP2D6TSHRKMT2A | |
| SCHEMBL11026647 | 0.81 | ALDH1A1 (0.56) | TSHRKMT2AKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040793-B1 | NOVEL QUINAZOLINE-DIONE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | Ishikawa, Masayuki (JP) | 1985-08-28 | — | — | EP | disclosed |
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |