Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281901 | 0.88 | CES2 (0.44) | CA1CA2CA4CA7LMNA | |
| SCHEMBL7311482 | 0.84 | TRPA1 (0.50) | CA1CA2CA4CA7LMNA | |
| SCHEMBL9477455 | 0.81 | CA1 (0.52) | CA1CA2CA4CA7LMNA | |
| SCHEMBL9477461 | 0.81 | CA1 (0.52) | CA1CA2CA4CA7LMNA | |
| SCHEMBL7272849 | 0.80 | MAPT (0.62) | LMNAHPGDSMN1; SMN2NPSR1MEN1 | |
| SCHEMBL9390821 | 0.80 | TRPA1 (0.47) | LMNAHPGDSMN1; SMN2TRPA1NPSR1 | |
| SCHEMBL16795914 | 0.80 | TRPA1 (0.47) | LMNAHPGDSMN1; SMN2TRPA1NPSR1 | |
| SCHEMBL11555112 | 0.78 | LMNA (0.40) | CA1CA2CA4CA7LMNA | |
| SCHEMBL11555113 | 0.78 | LMNA (0.40) | CA1CA2CA4CA7LMNA | |
| SCHEMBL7610520 | 0.77 | CA1 (0.36) | CA1CA2CA4CA7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0060674-B1 | DIHYDROPYRIDINE ANTI-ISCHAEMIC AND ANTIHYPERTENSIVE AGENTS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pfizer Limited (GB) | 1985-09-18 | — | — | EP | disclosed |
| EP-0060674-A1 | Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them | Pfizer Limited (GB) | 1982-09-22 | — | — | EP | disclosed |