Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.37 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11022206 | 0.93 | ABL1 (0.47) | ABL1PDE5AMAPTMEN1KMT2A | |
| SCHEMBL11022136 | 0.92 | MAPT (0.39) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL11020909 | 0.84 | PDE7A (0.41) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL11018034 | 0.82 | RHEB (0.39) | MAPTMEN1KMT2APOLBLMNA | |
| SCHEMBL11018593 | 0.82 | TP53 (0.46) | MAPTPOLBLMNATP53SMN1; SMN2 | |
| SCHEMBL11018199 | 0.81 | CHEK2 (0.51) | — | |
| SCHEMBL11017854 | 0.80 | MAOB (0.43) | PDE5AMAPTMEN1KMT2ALMNA | |
| SCHEMBL11018823 | 0.78 | TOP1 (0.40) | PDE5AMAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL11021215 | 0.78 | AMY1A (0.45) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL10763812 | 0.77 | ABL1 (0.43) | ABL1MAPTHPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |