Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11026344 | 0.88 | ALOX5 (0.37) | ALOX5ALOX15MAPTTP53PPARG | |
| SCHEMBL9740950 | 0.71 | ALOX5 (0.46) | ALOX5ALOX15PPARGPPARAKDM4E | |
| SCHEMBL9742551 | 0.71 | ALOX5 (0.61) | ALOX5ALOX15MAPTRAB9ANPC1 | |
| SCHEMBL9740742 | 0.70 | ALOX5 (0.37) | ALOX5ALOX15MAPTTP53PPARG | |
| SCHEMBL9740445 | 0.69 | ALOX5 (0.64) | ALOX5ALOX15MAPTRAB9ANPC1 | |
| SCHEMBL9739661 | 0.69 | ALOX5 (0.72) | ALOX5ALOX15 | |
| SCHEMBL10513827 | 0.68 | ALOX5 (0.45) | ALOX5ALOX15MAPTTP53RAB9A | |
| SCHEMBL9742153 | 0.66 | ALOX5 (0.55) | ALOX5ALOX15PPARGPPARAHSD17B10 | |
| SCHEMBL9742519 | 0.64 | ALOX5 (0.69) | ALOX5ALOX15 | |
| SCHEMBL9739893 | 0.64 | ALOX5 (0.54) | ALOX5ALOX15MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |