Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739138 | 0.72 | ALOX5 (0.68) | ALOX5ALOX15MAPTPOLBLMNA | |
| SCHEMBL9742153 | 0.66 | ALOX5 (0.55) | ALOX5ALOX15KDM4EPPARGPPARA | |
| SCHEMBL9739854 | 0.66 | ALOX5 (0.64) | ALOX5ALOX15MAPTPOLBLMNA | |
| SCHEMBL5105195 | 0.64 | PTPN1 (0.44) | KDM4EPPARGPPARAHSD17B10CA12 | |
| SCHEMBL9740742 | 0.63 | ALOX5 (0.37) | ALOX5ALOX15MAPTTP53PPARG | |
| SCHEMBL9739893 | 0.62 | ALOX5 (0.54) | ALOX5ALOX15MAPTKDM4ENPC1 | |
| SCHEMBL9739158 | 0.60 | PRKCI (0.42) | ALOX5TSHRKDM4EPPARGPPARA | |
| SCHEMBL6941063 | 0.60 | GAA (0.64) | MAPTTSHRTP53KDM4EPOLB | |
| SCHEMBL3609779 | 0.59 | L3MBTL1 (0.48) | ALOX5MAPTKDM4ENPC1RAB9A | |
| SCHEMBL570567 | 0.58 | LMNA (0.67) | MAPTNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |