Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CREB1 | P16220 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739801 | 0.81 | ALOX5 (0.67) | ALOX5KDM4EALDH1A1ALOX15 | |
| SCHEMBL9740445 | 0.77 | ALOX5 (0.64) | ALOX5ALOX15FPR1 | |
| SCHEMBL9741057 | 0.77 | ALOX5 (0.44) | ALOX5KDM4EALDH1A1ALOX15PPARG | |
| SCHEMBL9742551 | 0.76 | ALOX5 (0.61) | ALOX5ALOX15 | |
| SCHEMBL9739661 | 0.75 | ALOX5 (0.72) | ALOX5ALDH1A1ALOX15FPR1 | |
| SCHEMBL11022249 | 0.71 | ALOX5 (0.35) | ALOX5KDM4EALOX15PPARGPPARA | |
| SCHEMBL9739794 | 0.71 | ALOX5 (0.44) | ALOX5KDM4EALDH1A1HPGDALOX15 | |
| SCHEMBL10738798 | 0.70 | KDM4E (0.39) | ALOX5ADORA3KDM4EALDH1A1HPGD | |
| SCHEMBL9740742 | 0.69 | ALOX5 (0.37) | ALOX5ALOX15PPARGPPARA | |
| SCHEMBL9739829 | 0.64 | ALOX5 (0.60) | ALOX5KDM4EALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |