Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22610054 | 0.85 | CYP2D6 (0.85) | CYP2D6CYP2C19ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL11020028 | 0.82 | ALDH1A1 (0.85) | CYP2D6CYP2C19ALDH1A1L3MBTL1CYP1A2 | |
| SCHEMBL10679697 | 0.81 | HRH3 (0.68) | HRH3 | |
| SCHEMBL11267638 | 0.80 | CYP2D6 (0.66) | CYP2D6CYP2C19ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL26194821 | 0.79 | CYP2D6 (0.69) | CYP2D6CYP2C19ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL8264564 | 0.79 | TDP1 (1.00) | CYP2D6CYP2C19ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL10992911 | 0.78 | CYP2D6 (0.83) | CYP2D6CYP2C19ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL4849189 | 0.78 | CYP2D6 (0.53) | CYP2D6CYP2C19ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL24445406 | 0.78 | CYP2D6 (0.68) | CYP2D6CYP2C19ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL11023435 | 0.78 | LMNA (0.57) | CYP2D6CYP2C19ALDH1A1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157652-A1 | 2-, 3- And 4-biphenyloxyaminoalkanes and related compounds, their preparation and uses, and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1985-10-09 | — | — | EP | disclosed |