Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11029634 | 1.00 | LMNA (0.42) | LMNAPLGPLATS1PR5HSD11B1 | |
| SCHEMBL18628984 | 0.88 | GRM2 (0.37) | LMNAPLGPLATS1PR5HSD11B1 | |
| SCHEMBL28858258 | 0.84 | HSD11B1 (0.36) | LMNAS1PR5HSD11B1GAAKDM4E | |
| SCHEMBL863219 | 0.83 | LMNA (0.42) | LMNAPLGPLATS1PR5HSD11B1 | |
| SCHEMBL16205299 | 0.82 | LMNA (0.41) | LMNAPLGPLATS1PR5HSD11B1 | |
| SCHEMBL881189 | 0.81 | LMNA (0.43) | LMNAPLGPLATHSD11B1GABRP | |
| SCHEMBL1769072 | 0.79 | GRM2 (0.35) | LMNAS1PR5GAAALDH1A1MAPT | |
| SCHEMBL2151480 | 0.79 | — | — | |
| SCHEMBL2675870 | 0.78 | LMNA (0.48) | LMNAPLGPLATHSD11B1GABRP | |
| SCHEMBL1835961 | 0.78 | GLA (0.50) | LMNAPLGPLATS1PR5HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077550-B1 | 1.4-NAPHTHOQUINONES, METHODS FOR THEIR PREPARATION AND VETERINARY FORMULATIONS THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-07-10 | — | — | EP | disclosed |
| EP-0077551-B1 | 1.4-NAPHTHOQUINONES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL AND VETERINARY FORMULATIONS THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-06-12 | — | — | EP | disclosed |
| US-4485117-A | ANTIMALARIAL AND ANTICOCCIDIAL; HYDROXYNAPHTHOQUINONES | BURROUGHS WELLCOME CO., A CORP OF NORTH CAROLINA | 1984-11-27 | — | — | US | disclosed |
| US-4485116-A | NAPHTHOQUINONE COMPOUNDS | BURROUGHS WELLCOME CO. | 1984-11-27 | — | — | US | disclosed |
| EP-0077550-A2 | 1.4-Naphthoquinones, methods for their preparation and veterinary formulations thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-04-27 | — | — | EP | disclosed |
| EP-0077551-A2 | 1.4-Naphthoquinones, methods for their preparation, pharmaceutical and veterinary formulations thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-04-27 | — | — | EP | disclosed |