Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11026806 | 0.92 | HRH4 (0.38) | KITALDH1A1LMNAHPGDTSHR | |
| SCHEMBL11028075 | 0.91 | HRH4 (0.39) | ALDH1A1LMNAHPGDTSHRMAPK1 | |
| SCHEMBL11026793 | 0.91 | ALDH1A1 (0.43) | KITALDH1A1LMNAHPGDTSHR | |
| SCHEMBL11044328 | 0.90 | HRH4 (0.40) | KITALDH1A1LMNAHPGDTSHR | |
| SCHEMBL11312367 | 0.90 | ACACB (0.35) | KITACACBALDH1A1LMNAHPGD | |
| SCHEMBL11026067 | 0.87 | NPC1 (0.31) | ALDH1A1HRH4 | |
| SCHEMBL11029550 | 0.86 | PDGFRB (0.34) | KITALDH1A1TSHRHTT | |
| SCHEMBL11046483 | 0.86 | ACACB (0.34) | ACACBCSNK1A1 | |
| SCHEMBL11047615 | 0.85 | HRH4 (0.40) | ACACBALDH1A1LMNAHPGDTSHR | |
| SCHEMBL11028231 | 0.85 | PDE5A (0.43) | KITALDH1A1LMNAHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055444-B1 | TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1985-03-20 | — | — | EP | disclosed |