Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 5/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11044328 | 0.89 | HRH4 (0.40) | KITPDE5ATSHRHTTALDH1A1 | |
| SCHEMBL11026067 | 0.87 | NPC1 (0.31) | ALDH1A1 | |
| SCHEMBL11026806 | 0.87 | HRH4 (0.38) | KITTSHRHTTALDH1A1 | |
| SCHEMBL11046232 | 0.86 | BCHE (0.33) | KITTSHRHTTALDH1A1KDM4E | |
| SCHEMBL11028075 | 0.86 | HRH4 (0.39) | TSHRHTTALDH1A1 | |
| SCHEMBL11023760 | 0.86 | KIT (0.34) | KITTSHRHTTALDH1A1 | |
| SCHEMBL11026793 | 0.86 | ALDH1A1 (0.43) | KITTLR9TLR7TSHRHTT | |
| SCHEMBL11025913 | 0.85 | SLC29A1 (0.33) | PDE5ATSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11028231 | 0.85 | PDE5A (0.43) | PDGFRBPDGFRAKITPDE5ATSHR | |
| SCHEMBL11312367 | 0.85 | ACACB (0.35) | KITTSHRHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055444-B1 | TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1985-03-20 | — | — | EP | disclosed |
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
| EP-0055444-A2 | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-07-07 | — | — | EP | disclosed |