Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | AKT2 | P31751 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11026806 | 0.92 | HRH4 (0.38) | HRH4LMNAHTTALDH1A1HPGD | |
| SCHEMBL11023760 | 0.91 | KIT (0.34) | HRH4LMNAHTTALDH1A1HPGD | |
| SCHEMBL11026793 | 0.91 | ALDH1A1 (0.43) | HRH4LMNAHTTALDH1A1HPGD | |
| SCHEMBL11026067 | 0.90 | NPC1 (0.31) | HRH4ALDH1A1AKT1AKT2 | |
| SCHEMBL11044328 | 0.90 | HRH4 (0.40) | HRH4LMNAHTTALDH1A1HPGD | |
| SCHEMBL11021816 | 0.88 | MEN1 (0.32) | HTTALDH1A1AKT1AKT2 | |
| SCHEMBL11031948 | 0.86 | CSF1R (0.32) | ALDH1A1HPGDTSHR | |
| SCHEMBL11029550 | 0.86 | PDGFRB (0.34) | HTTALDH1A1TSHR | |
| SCHEMBL11026550 | 0.86 | CNR2 (0.33) | LMNAALDH1A1HPGDAKT1AKT2 | |
| SCHEMBL11028231 | 0.85 | PDE5A (0.43) | LMNAHTTALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055444-B1 | TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1985-03-20 | — | — | EP | disclosed |
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
| EP-0055444-A2 | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-07-07 | — | — | EP | disclosed |