Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.41 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | NEK4 | P51957 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037271 | 0.86 | SIRT6 (0.57) | CHEK1KDRGSK3AGSK3BPDPK1 | |
| SCHEMBL27818231 | 0.85 | CHEK1 (0.40) | CHEK1KDRGSK3AGSK3BPDPK1 | |
| Water SCHEMBL28665454 | 0.82 | KDM4E (0.56) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| Water SCHEMBL336347 | 0.82 | KDM4E (0.56) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| SCHEMBL24724182 | 0.82 | KCNJ1 (0.40) | CHEK1KDRGSK3AGSK3BPDPK1 | |
| SCHEMBL70035 | 0.79 | KDM4E (0.59) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| SCHEMBL30859509 | 0.77 | P4HTM (0.44) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| Iodide SCHEMBL6129698 | 0.77 | KDM4E (0.52) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| Water SCHEMBL6129699 | 0.77 | KDM4E (0.52) | KDM4EHCAR2NAPRTP4HTMP4HA1 | |
| SCHEMBL7767700 | 0.77 | KDM4E (0.56) | KDM4EHCAR2NAPRTP4HTMP4HA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104470915-B | Difluoro-hexahydro-cyclopentoxazines and difluoro-hexahydro-benzoxazines as BACE1 inhibitors | 霍夫曼-拉罗奇有限公司 | 2019-07-26 | — | — | CN | claimed |
| EP-2864324-B1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-28 | — | — | EP | claimed |
| US-9181232-B2 | Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as BACE1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2015-11-10 | — | — | US | claimed |
| US-20150133440-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2015-05-14 | — | — | US | claimed |
| EP-2864324-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-04-29 | — | — | EP | claimed |
| CN-104470915-A | Difluoro-hexahydro-cyclopentoxazines and difluoro-hexahydro-benzoxazines as BACE1 inhibitors | HOFFMANN LA ROCHE | 2015-03-25 | — | — | CN | claimed |
| WO-2014001228-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-03 | — | — | WO | claimed |
| WO-2022155419-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | ESCAPE Bio, Inc. (US) | 2022-07-21 | — | — | WO | disclosed |
| CN-104470915-B | Difluoro-hexahydro-cyclopentoxazines and difluoro-hexahydro-benzoxazines as BACE1 inhibitors | 霍夫曼-拉罗奇有限公司 | 2019-07-26 | — | — | CN | disclosed |
| EP-2864324-B1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-28 | — | — | EP | disclosed |
| CN-103328486-B | Fused aminodihydrothiazine derivatives useful as bace inhibitors | 卫材R&D管理有限公司 | 2016-08-17 | — | — | CN | disclosed |
| EP-2665732-B1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES USEFUL AS BACE INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2016-03-30 | — | — | EP | disclosed |
| US-9181232-B2 | Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as BACE1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2015-11-10 | — | — | US | disclosed |
| EP-2665732-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES USEFUL AS BACE INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2013-11-27 | — | — | EP | disclosed |
| US-8592408-B2 | Fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-11-26 | — | — | US | disclosed |
| CN-103328486-A | Fused aminodihydrothiazine derivatives useful as BACE inhibitors | EISAI R&D MAN CO LTD | 2013-09-25 | — | — | CN | disclosed |
| US-20130203740-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-08 | — | — | US | disclosed |
| US-8338407-B2 | Fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-12-25 | — | — | US | disclosed |
| WO-2012098213-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES USEFUL AS BACE INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | WO | disclosed |
| US-20120190672-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190672-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, APP, BACE2 | KDM4E 655/4885HCAR2 2437/4885NAPRT 3696/4885 |
| US-20130203740-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, APP, BACE2 | KDM4E 655/4885HCAR2 2437/4885NAPRT 3696/4885 |
| US-20150133440-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | BACE1, BACE2, PSEN1 | KDM4E 1439/4885HCAR2 2682/4885NAPRT 1851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.