Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11026647 | 0.90 | ALDH1A1 (0.56) | KDM4EGAALMNAALDH1A1KMT2A | |
| SCHEMBL11023279 | 0.84 | CYP2D6 (0.49) | KDM4EGAAALDH1A1HRH3MAPK1 | |
| SCHEMBL25475311 | 0.83 | KDM4E (0.50) | KDM4EGAAPKMLMNAEPHX2 | |
| SCHEMBL13265466 | 0.83 | HRH3 (0.54) | KDM4EGAAPKMLMNAEPHX2 | |
| SCHEMBL561431 | 0.83 | SMN1; SMN2 (0.52) | KDM4EGAAPKMLMNAEPHX2 | |
| SCHEMBL11023682 | 0.83 | CYP2D6 (0.51) | KDM4EALDH1A1HRH3MAPK1CYP1A2 | |
| SCHEMBL8560963 | 0.83 | KDM4E (0.52) | KDM4EGAAPKMLMNAEPHX2 | |
| SCHEMBL11025698 | 0.81 | HRH3 (0.47) | KDM4ELMNAALDH1A1HRH3MAPK1 | |
| SCHEMBL16845053 | 0.81 | KDM4E (0.54) | KDM4EGAAPKMLMNAEPHX2 | |
| SCHEMBL25475255 | 0.81 | ALDH1A1 (0.49) | KDM4EGAAPKMLMNAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040793-B1 | NOVEL QUINAZOLINE-DIONE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | Ishikawa, Masayuki (JP) | 1985-08-28 | — | — | EP | disclosed |
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |