Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11023279 | 0.98 | CYP2D6 (0.49) | CYP2D6SMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL11026771 | 0.95 | MEN1 (0.51) | CYP2D6SMN1; SMN2CYP1A2MAPK1HRH3 | |
| SCHEMBL11026149 | 0.89 | SIGMAR1 (0.50) | CYP2D6KDM4EALDH1A1CYP1A2MAPK1 | |
| SCHEMBL11023837 | 0.87 | SIGMAR1 (0.51) | CYP2D6KDM4EALDH1A1CYP1A2HRH3 | |
| SCHEMBL11029744 | 0.86 | CYP2D6 (0.49) | CYP2D6SMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL11025698 | 0.84 | HRH3 (0.47) | CYP2D6SMN1; SMN2KDM4EALDH1A1MAPK1 | |
| SCHEMBL11024196 | 0.83 | KDM4E (0.50) | SMN1; SMN2KDM4EALDH1A1CYP1A2MAPK1 | |
| SCHEMBL8562390 | 0.81 | CYP2D6 (0.54) | CYP2D6SMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL16829927 | 0.81 | CYP2D6 (0.57) | CYP2D6SMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL8560879 | 0.79 | KDM4E (0.51) | CYP2D6SMN1; SMN2KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040793-B1 | NOVEL QUINAZOLINE-DIONE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | Ishikawa, Masayuki (JP) | 1985-08-28 | — | — | EP | disclosed |
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |