Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 4/20 | 0.36 |
| ▸ | F11 | P03951 | 4/20 | 0.36 |
| ▸ | F7 | P08709 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.35 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.35 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025475 | 0.92 | KMO (0.40) | F10F11F7MAPTGSK3B | |
| SCHEMBL11025709 | 0.87 | F7 (0.44) | F10F11F7MAPTPLOD2 | |
| SCHEMBL11028354 | 0.87 | SIRT2 (0.45) | MAPTGSK3BPIK3CAMEN1ALDH1A1 | |
| SCHEMBL11027051 | 0.86 | CHEK1 (0.40) | MAPTGSK3BCHEK1PRKAG1PRKAA1 | |
| SCHEMBL11029216 | 0.85 | PRKAG1 (0.41) | F10F11F7MAPTPRKAG1 | |
| SCHEMBL11940904 | 0.85 | SCN9A (0.40) | MAPTGSK3BRIPK2 | |
| SCHEMBL11027123 | 0.85 | MAPT (0.36) | CHRNB2CHRNA4F10F11F7 | |
| SCHEMBL11028020 | 0.81 | PRKAG1 (0.40) | MAPTPRKAG1PRKAA1PRKAB1MEN1 | |
| SCHEMBL11028243 | 0.80 | PRKAG1 (0.39) | MAPTPRKAG1PRKAA1PRKAB1MEN1 | |
| SCHEMBL11026479 | 0.80 | CYP2C19 (0.41) | F10F11F7MAPTPRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809369-B2 | Tetrahydroquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | RAB1A, RABL3, RAB7A | MKNK1 3383/4885MKNK2 3048/4885CHRNB2 2559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.