Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11028167 | 0.83 | ACHE (0.41) | ACHEPLA2G10PLA2G5KMT2ACASP3 | |
| SCHEMBL8924334 | 0.76 | RAMP1 (0.50) | PLA2G10PLA2G5KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL31421464 | 0.75 | ACHE (0.49) | ACHEKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL24714971 | 0.72 | ALDH1A1 (0.60) | KMT2AL3MBTL1MEN1ALDH1A1 | |
| SCHEMBL11327841 | 0.69 | HPGD (0.58) | KMT2AMEN1HPGDALDH1A1PKM | |
| SCHEMBL29890980 | 0.68 | ACHE (0.64) | ACHEL3MBTL1PKM | |
| SCHEMBL8825578 | 0.68 | ACHE (0.64) | ACHEL3MBTL1PKM | |
| SCHEMBL10954499 | 0.68 | PLA2G10 (0.43) | PLA2G10PLA2G5HPGD | |
| SCHEMBL12638925 | 0.67 | KMT2A (0.61) | ACHEKMT2AL3MBTL1TDP1MEN1 | |
| SCHEMBL30191344 | 0.67 | PLA2G10 (0.44) | ACHEPLA2G10PLA2G5KMT2ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049842-B1 | SUBSTITUTED ENANTHOLACTAM DERIVATIVES, A PROCESS FOR THE PREPARATION AND A PHARMACEUTICAL COMPOSITION USEFUL IN THE TREATMENT OF HYPERTENSION COMPRISING THE SAME, AND INTERMEDIATES | MERCK & CO. INC. (US) | 1985-08-28 | — | — | EP | disclosed |
| US-4396616-A | DIURETICS, ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1983-08-02 | — | — | US | disclosed |
| EP-0049842-A2 | Substituted enantholactam derivatives, a process for the preparation and a pharmaceutical composition useful in the treatment of hypertension comprising the same, and intermediates | MERCK & CO. INC. (US) | 1982-04-21 | — | — | EP | disclosed |