Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAMP1 | O60894 | 3/20 | 0.50 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.46 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13929747 | 0.86 | RAMP1 (0.50) | RAMP1CALCRLPLA2G10PLA2G5RIPK1 | |
| SCHEMBL8921216 | 0.86 | RAMP1 (0.50) | RAMP1CALCRLPLA2G10PLA2G5RIPK1 | |
| SCHEMBL13929783 | 0.83 | RAMP1 (0.56) | RAMP1CALCRLPLA2G10PLA2G5RIPK1 | |
| SCHEMBL13951818 | 0.82 | RAMP1 (0.56) | RAMP1CALCRLPLA2G10PLA2G5RIPK1 | |
| SCHEMBL8924459 | 0.77 | PLA2G10 (0.44) | RAMP1CALCRLPLA2G10PLA2G5RIPK1 | |
| SCHEMBL11028111 | 0.76 | ACHE (0.41) | PLA2G10PLA2G5ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL9526266 | 0.74 | PLA2G10 (0.44) | RAMP1CALCRLPLA2G10PLA2G5RIPK1 | |
| SCHEMBL9526268 | 0.74 | PLA2G10 (0.44) | RAMP1CALCRLPLA2G10PLA2G5RIPK1 | |
| SCHEMBL8920349 | 0.74 | RAMP1 (0.42) | RAMP1CALCRLPLA2G10PLA2G5ALDH1A1 | |
| SCHEMBL8921722 | 0.74 | RAMP1 (0.41) | RAMP1CALCRLPLA2G10PLA2G5CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |
| US-4757068-A | Lactams and bicyclic lactams useful as cholecystokinin antagonists | MERCK & CO., INC. (US) | 1988-07-12 | — | — | US | disclosed |
| US-4680392-A | Substituted caprolactam derivatives as antihypertensives | MERCK & CO., INC. (US) | 1987-07-14 | — | — | US | disclosed |
| US-4629787-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0046291-B1 | SUBSTITUTED CAPROLACTAM DERIVATIVES AS ANTIHYPERTENSIVES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND INTERMEDIATES | MERCK & CO. INC. (US) | 1985-12-27 | — | — | EP | disclosed |
| EP-0046291-A2 | Substituted caprolactam derivatives as antihypertensives, process for preparing them, pharmaceutical composition containing them, and intermediates | MERCK & CO. INC. (US) | 1982-02-24 | — | — | EP | disclosed |