Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.42 |
| ▸ | F10 | P00742 | 11/20 | 0.40 |
| ▸ | F11 | P03951 | 11/20 | 0.40 |
| ▸ | F7 | P08709 | 11/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025182 | 0.92 | F11 (0.40) | MKNK1MKNK2F10F11F7 | |
| SCHEMBL11025278 | 0.87 | F11 (0.51) | F10F11F7 | |
| SCHEMBL11024143 | 0.86 | MAP4K4 (0.35) | F10F11F7MAP4K4 | |
| SCHEMBL11940913 | 0.84 | SCN9A (0.37) | F10F11F7 | |
| SCHEMBL11029252 | 0.79 | F7 (0.45) | MKNK1MKNK2F10F11F7 | |
| SCHEMBL11028151 | 0.79 | F10 (0.32) | MKNK1MKNK2F10F11F7 | |
| SCHEMBL11023687 | 0.78 | F11 (0.50) | F10F11F7 | |
| SCHEMBL11026607 | 0.75 | MKNK1 (0.39) | MKNK1MKNK2F10F11F7 | |
| SCHEMBL11025597 | 0.74 | F11 (0.42) | F10F11F7 | |
| SCHEMBL11024124 | 0.73 | F11 (0.43) | F10F11F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809369-B2 | Tetrahydroquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-08-19 | — | — | US | claimed |
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | US | claimed |
| US-8809369-B2 | Tetrahydroquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-08-19 | — | — | US | disclosed |
| EP-2668165-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101068-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | RAB1A, RABL3, RAB7A | MKNK1 3383/4885MKNK2 3048/4885F10 2432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.