Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | MITF | O75030 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 2/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.40 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856931 | 0.86 | CDC25B (0.46) | MAPTLMNATDP1ALDH1A1HTT | |
| SCHEMBL917110 | 0.86 | CDC25B (0.46) | MAPTLMNATDP1ALDH1A1HTT | |
| SCHEMBL8444855 | 0.84 | CDC25B (0.45) | MAPTLMNATDP1ALDH1A1HTT | |
| SCHEMBL11057934 | 0.78 | IDO1 (0.40) | MAPTLMNATDP1ALDH1A1HTT | |
| SCHEMBL11120217 | 0.75 | IDO1 (0.52) | MAPTLMNAALDH1A1HTTMITF | |
| SCHEMBL916442 | 0.75 | IDO1 (0.52) | MAPTLMNAALDH1A1HTTMITF | |
| SCHEMBL9682118 | 0.74 | IDO1 (0.44) | MAPTLMNATDP1ALDH1A1HTT | |
| SCHEMBL1542662 | 0.73 | KMT2A (0.68) | MAPTLMNAALDH1A1HTTUSP2 | |
| SCHEMBL917397 | 0.73 | KMT2A (0.68) | MAPTLMNAALDH1A1HTTUSP2 | |
| SCHEMBL12589641 | 0.73 | KMT2A (0.68) | MAPTLMNAALDH1A1HTTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077551-B1 | 1.4-NAPHTHOQUINONES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL AND VETERINARY FORMULATIONS THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-06-12 | — | — | EP | disclosed |
| US-4485117-A | ANTIMALARIAL AND ANTICOCCIDIAL; HYDROXYNAPHTHOQUINONES | BURROUGHS WELLCOME CO., A CORP OF NORTH CAROLINA | 1984-11-27 | — | — | US | disclosed |
| EP-0077551-A2 | 1.4-Naphthoquinones, methods for their preparation, pharmaceutical and veterinary formulations thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-04-27 | — | — | EP | disclosed |