Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.78 |
| ▸ | PPARA | Q07869 | 2/20 | 0.72 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.68 |
| ▸ | PPARG | P37231 | 1/20 | 0.67 |
| ▸ | RARA | P10276 | 2/20 | 0.61 |
| ▸ | RARG | P13631 | 1/20 | 0.61 |
| ▸ | PLK1 | P53350 | 6/20 | 0.59 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5609669 | 1.00 | RARB (0.78) | RARBPPARAKAT8PPARGRARA | |
| SCHEMBL4308582 | 1.00 | RARB (0.78) | RARBPPARAKAT8PPARGRARA | |
| SCHEMBL20503376 | 1.00 | RARB (0.78) | RARBPPARAKAT8PPARGRARA | |
| SCHEMBL551744 | 0.93 | RARB (0.68) | RARBPPARAKAT8PPARGRARA | |
| SCHEMBL4187659 | 0.88 | RARB (1.00) | RARBPPARAKAT8PPARGRARA | |
| SCHEMBL4611393 | 0.88 | RARB (1.00) | RARBPPARAKAT8PPARGRARA | |
| SCHEMBL3033031 | 0.87 | KAT8 (0.77) | RARBPPARAKAT8PPARGRARA | |
| SCHEMBL10792437 | 0.87 | KAT8 (0.77) | RARBPPARAKAT8PPARGRARA | |
| SCHEMBL9665751 | 0.87 | KAT8 (0.77) | RARBPPARAKAT8PPARGRARA | |
| SCHEMBL3029363 | 0.87 | KAT8 (0.77) | RARBPPARAKAT8PPARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673882-B2 | Inhibitors of autotaxin | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2014-03-18 | — | — | US | disclosed |
| WO-2012100018-A1 | INHIBITORS OF AUTOTAXIN | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2012-07-26 | — | — | WO | disclosed |
| US-20120190650-A1 | Inhibitors of Autotaxin | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190650-A1 | Inhibitors of Autotaxin | ENPP2, PHPT1, PSPH | RARB 3143/4885PPARA 3412/4885KAT8 2965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.