Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370189 | 0.86 | CA2 (0.56) | KDM4ELARS1KMT2AEGFRERBB2 | |
| SCHEMBL5605338 | 0.84 | CA2 (0.54) | KDM4ELARS1KMT2AEGFRERBB2 | |
| SCHEMBL29176138 | 0.80 | HTR6 (0.52) | KDM4ELARS1KMT2AMEN1GAA | |
| Ether SCHEMBL11798801 | 0.79 | KDM4E (0.49) | KDM4ELARS1KMT2AEGFRERBB2 | |
| Sulfhydryl Boron Hydride SCHEMBL11784995 | 0.77 | GAA (0.58) | KDM4EKMT2ATSHRGAAALDH1A1 | |
| SCHEMBL4700005 | 0.77 | SMN1; SMN2 (0.57) | KDM4EKMT2AEGFRERBB2TSHR | |
| SCHEMBL29030151 | 0.76 | BCAT1 (0.43) | KDM4ELARS1KMT2AEGFRERBB2 | |
| SCHEMBL23002422 | 0.74 | KMT2A (0.54) | KDM4EKMT2AEGFRERBB2TSHR | |
| SCHEMBL386093 | 0.74 | KDM4E (0.57) | KDM4ELARS1EGFRERBB2CA2 | |
| Diphenylmethane SCHEMBL28246450 | 0.74 | GAA (0.56) | KMT2AEGFRERBB2GAACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073507-B1 | SULFONYL UREAS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-10-16 | — | — | EP | claimed |
| EP-0031058-B1 | SULFONYL UREAS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-04-04 | — | — | EP | claimed |
| US-4542139-A | HYPOGLYCEMIC AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-09-17 | — | — | US | disclosed |
| US-4379785-A | Heterocyclic substituted sulfonyl ureas, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-04-12 | — | — | US | disclosed |
| US-4379153-A | Benzenesulfonyl ureas, and pharmaceutical preparations | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-04-05 | — | — | US | disclosed |
| US-4157395-A | TREATMENT OF DIABETES | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-06-05 | — | — | US | disclosed |
| US-4132795-A | Benzenesulfonyl ureas and their use for the treatment of diabetes mellitus | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-02 | — | — | US | disclosed |
| US-4083979-A | Thiazolidine derivatives and their use as salidiuretics | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-04-11 | — | — | US | disclosed |
| US-4025519-A | HYPOGLYCEMIC AGENTS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-05-24 | — | — | US | disclosed |
| US-3962244-A | LOWERING OF BLOOD-SUGAR LEVELS | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-06-08 | — | — | US | disclosed |
| US-3939269-A | Benzenesulfon YL-semicarbazides for lowering blood sugar levels | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-02-17 | — | — | US | disclosed |
| US-3932658-A | Composition and method for lower blood sugar containing N-[4-(β-<2-methoxy-5-chloro-benzamido>-ethyl)-benzenesulfonyl]-N'-cyclopentyl-urea | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-01-13 | — | — | US | disclosed |